The game's World Domination mode allows players to battle across a virtual earth which is split into many sections/provinces. In Empire Earth III, each region focuses on different styles of game play for example, the Middle East has mobile buildings, the West has a few powerful units, and the Far East has masses of weak, swarming units combined with powerful mutants in the future. Another new feature in Empire Earth III is certain nuclear weapons such as a nuclear cannon.
the Far Eastern civilization contains China and Japan). Furthermore, each civilization features subfactions based on historical nations (e.g. Each civilization can be customized by the player to their choosing. There are three customizable civilizations to choose from which are Western, Middle-Eastern, and Far Eastern.
However, unlike Total War, the player advances through the entire course of history rather than staying in a specific time period. It introduces several new units and weapons, as well as a new free-form campaign structure that is similar in style to other real-time strategy games, such as the Total War series. Similar to its predecessors, Empire Earth III is a real-time strategy game.